Sample type: Serum

Test name: Tissue Transglutaminase Antibody a.k.a. TTG

Condition / Indication: Coeliac

Special precautions & notes: The anti-tissue transglutaminase (tTG)assay is an IgA based assay, used as the primary screen for coeliac disease at NBT. Positive results are reflexed for a confirmatory IgA anti-endomysial (EMA)) assay. If the IgA tTG result is below a designated assay value, the sample will be checked for IgA deficiency, and if the IgA is <0.2g/l,  an IgG EMA test will be performed. Appropriate additional comments will be added to the final report. Please note, diagnostic coeliac serology should be undertaken while the patient is on a gluten containing diet.

IgA deficiency is common and usually asymptomatic. IgA results <0.5gl/ wil reflex IgG and IgM assessment to look for wider antibody deficiency

Container: Serum (Gold top)

Ideal volume (mL): 2 mL

Referred outside NBT for analysis? No

Discipline: Immunology

Turnaround time: 7 working days